TESTICULAR HISTOMORPHOLOGY; EFFECTS OF RECOMBINANT HUMAN INTERFERON-α-2B IN ALBINO RAT MODEL
نویسندگان
چکیده
منابع مشابه
The Effect of Heat Shock on Production of Recombinant Human Interferon Alpha 2a (rhIFN α -2a) by Escherichia coli
Recombinant human interferon alpha 2a (rhIFN α -2a) production and cell growth were monitored in a set of genetically modified E. coli strains (MSD1519, MSD1520, MSD 1521, MSD 1522, MSD 1523) producing rhIFN α -2a. The growth was followed at OD 600 nm, changes in cell physiology were detected by pyrolysis mass spectrometry (PyMS) of cell biomass and recombinant protein production was determined...
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PURPOSE We successfully developed recombinant human interferon alpha-2b (rhIFN- α 2b) and mutein forms through the site-directed mutagenesis technique. The mutein forms were developed by substituting cysteins at positions 2 and 99 with aspartic acids. The potential adverse effects of these rhIFN- α 2bs were assessed by acute and subchronic studies. METHODS In the acute study, rhIFN- α 2bs wer...
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Human Interferon β (INF-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. In this study an expression vector was designed and constructed for expression of human INF-β-1b either in shake flasks and bench top bioreactor. The designed vector was constructed based upon pET-25b(+) with T7 promoter. Recombinant human beta interferon ...
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ژورنال
عنوان ژورنال: THE PROFESSIONAL MEDICAL JOURNAL
سال: 2016
ISSN: 1024-8919,2071-7733
DOI: 10.17957/tpmj/16.3445